{"id":1862,"date":"2023-08-28T22:56:58","date_gmt":"2023-08-28T20:56:58","guid":{"rendered":"http:\/\/localhost:8888\/progetti\/laramed\/?page_id=1862"},"modified":"2024-02-26T18:08:07","modified_gmt":"2024-02-26T17:08:07","slug":"pharma","status":"publish","type":"page","link":"https:\/\/web.infn.it\/LARAMED\/pharma\/","title":{"rendered":"Pharma"},"content":{"rendered":"<style>.wp-block-kadence-advancedheading.kt-adv-heading1862_b22aa4-9f, .wp-block-kadence-advancedheading.kt-adv-heading1862_b22aa4-9f[data-kb-block=\"kb-adv-heading1862_b22aa4-9f\"]{text-align:center;font-size:var(--global-kb-font-size-md, 1.25rem);font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading1862_b22aa4-9f mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading1862_b22aa4-9f[data-kb-block=\"kb-adv-heading1862_b22aa4-9f\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading1862_b22aa4-9f img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading1862_b22aa4-9f[data-kb-block=\"kb-adv-heading1862_b22aa4-9f\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading1862_b22aa4-9f wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading1862_b22aa4-9f\"><strong> Radiopharmacy<\/strong><\/h2>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color\">An example of the LARAMED team expertise on radiopharmacy are results obtained within the <a href=\"https:\/\/web.infn.it\/LARAMED\/metrics\/\" data-type=\"page\" data-id=\"628\">METRICS<\/a> project (acronym for Multimodal pET\/mRi Imaging with Cyclotron produced <strong><sup>51\/52<\/sup>Mn<\/strong> iSotopes), which aims to develop the technology needed to obtain a cyclotron driven production of <strong><sup>51\/52<\/sup>Mn<\/strong> PET radionuclides and to achieve PET\/MRI hybrid imaging in combination with paramagnetic <strong>Mn<\/strong>(II) compounds.<\/p>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color\">An overview of the recent activities carried out in order to develop a new class of <strong>Mn<\/strong>(II) dithiocarbamates complexes which can potentially be used as magnetic resonance imaging contrast media is given below.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"550\" height=\"272\" src=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/09\/image.png\" alt=\"Mn complexes\" class=\"wp-image-1929\" style=\"width:344px;height:170px\" srcset=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/09\/image.png 550w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/09\/image-300x148.png 300w\" sizes=\"(max-width: 550px) 100vw, 550px\" \/><figcaption class=\"wp-element-caption\">Mn complexes<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"has-theme-palette-3-color has-text-color\">&nbsp;The <strong>Mn<\/strong>(II) complexes were prepared by reacting MnCl2\u22194H2O(<strong>Mn1<\/strong>) with the PTA or dithiocarbamate ligands.<\/p>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color\">The[ <strong>Mn<\/strong>(II)(L)2] (<strong>Mn2<\/strong>,<strong>Mn3<\/strong>and<strong>Mn4<\/strong>) complexes were prepared by adding 5mL Milli-Q water containing MnCl2\u22194H2O to two equivalents of the sodium salt of the ligand L and L&#8217; (L=[(CH3CH2)2-N-C(=S)S-], or [(CH3CH2OCH2CH2)2-N-C(=S)S and L\u2019=[C7H12O2-N-C(=S)S-]) under inert conditions.<\/p>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color\">All complexes were characterised with elemental, ESI(+)MS, infrared (IR) and magneto-metric analysis. The magnetic measurements on the Mn complexes were carried out using a Superconducting Quantum Interference Device (SQUID) magnetometer, operating with a maximum applied field H=50kOe. Both longitudinal (T1) and transverse relaxation times (T2) were measured by appropriate spin-echo sequences.<\/p>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color\">The longitudinal (r1=1\/T1) and transverse (r2=1\/T2) relaxation rates were measured at 25\u00b0C at two magnetic field strengths: 0.5T and 1.5T (corresponding to 20 MHz and 60 MHz proton Larmor frequency) on a Stelar Spinmaster spectrometer working at adjustable field.<\/p>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color\">The relaxation times of the solutions containing Gadobenato dimeglumina and the <strong>Mn<\/strong> chelates were also measured in the concentration ranges between 0.01 and 5.0 mmol\/L with MRI phantom measurements at 1.5 T with a clinical SIEMENS Magnetom Aera of 1.5 T.<\/p>\n\n\n<style>.wp-block-kadence-advancedbtn.kb-btns1862_f9e0da-7d{gap:var(--global-kb-gap-xs, 0.5rem );justify-content:center;align-items:center;}.kt-btns1862_f9e0da-7d .kt-button{font-weight:normal;font-style:normal;}.kt-btns1862_f9e0da-7d .kt-btn-wrap-0{margin-right:5px;}.wp-block-kadence-advancedbtn.kt-btns1862_f9e0da-7d .kt-btn-wrap-0 .kt-button{color:#555555;border-color:#555555;}.wp-block-kadence-advancedbtn.kt-btns1862_f9e0da-7d .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns1862_f9e0da-7d .kt-btn-wrap-0 .kt-button:focus{color:#ffffff;border-color:#444444;}.wp-block-kadence-advancedbtn.kt-btns1862_f9e0da-7d .kt-btn-wrap-0 .kt-button::before{display:none;}.wp-block-kadence-advancedbtn.kt-btns1862_f9e0da-7d .kt-btn-wrap-0 .kt-button:hover, .wp-block-kadence-advancedbtn.kt-btns1862_f9e0da-7d .kt-btn-wrap-0 .kt-button:focus{background:#444444;}<\/style>\n<div class=\"wp-block-kadence-advancedbtn kb-buttons-wrap kb-btns1862_f9e0da-7d\"><style>ul.menu .wp-block-kadence-advancedbtn .kb-btn1862_ccd67b-33.kb-button{width:initial;}.wp-block-kadence-advancedbtn .kb-btn1862_ccd67b-33.kb-button{color:var(--global-palette3, #1A202C);background:var(--global-palette8, #F7FAFC);border-top-left-radius:5px;border-top-right-radius:5px;border-bottom-right-radius:5px;border-bottom-left-radius:5px;border-top:2px solid;border-right:2px solid;border-bottom:2px solid;border-left:2px solid;}@media all and (max-width: 1024px){.wp-block-kadence-advancedbtn .kb-btn1862_ccd67b-33.kb-button{border-top:2px solid;border-right:2px solid;border-bottom:2px solid;border-left:2px solid;}}@media all and (max-width: 767px){.wp-block-kadence-advancedbtn .kb-btn1862_ccd67b-33.kb-button{border-top:2px solid;border-right:2px solid;border-bottom:2px solid;border-left:2px solid;}}<\/style><a class=\"kb-button kt-button button kb-btn1862_ccd67b-33 kt-btn-size-standard kt-btn-width-type-auto kb-btn-global-fill  kt-btn-has-text-true kt-btn-has-svg-false  wp-block-kadence-singlebtn\" href=\"https:\/\/web.infn.it\/LARAMED\/technology\/\"><span class=\"kt-btn-inner-text\">Back<\/span><\/a><\/div>\n\n\n\n<p> <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Radiopharmacy An example of the LARAMED team expertise on radiopharmacy are results obtained within the METRICS project (acronym for Multimodal pET\/mRi Imaging with Cyclotron produced 51\/52Mn iSotopes), which aims to develop the technology needed to obtain a cyclotron driven production of 51\/52Mn PET radionuclides and to achieve PET\/MRI hybrid imaging in combination with paramagnetic Mn(II)&#8230;<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_themeisle_gutenberg_block_has_review":false,"_kad_post_transparent":"disable","_kad_post_title":"","_kad_post_layout":"normal","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-1862","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages\/1862","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/comments?post=1862"}],"version-history":[{"count":5,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages\/1862\/revisions"}],"predecessor-version":[{"id":2831,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages\/1862\/revisions\/2831"}],"wp:attachment":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/media?parent=1862"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}