{"id":1893,"date":"2023-08-30T11:08:56","date_gmt":"2023-08-30T09:08:56","guid":{"rendered":"http:\/\/localhost:8888\/progetti\/laramed\/?page_id=1893"},"modified":"2026-10-05T11:02:35","modified_gmt":"2026-10-05T09:02:35","slug":"laramed","status":"publish","type":"page","link":"https:\/\/web.infn.it\/LARAMED\/","title":{"rendered":"Laramed"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"876\" height=\"219\" src=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/SPES-cyclotron_v5.jpg\" alt=\"\" class=\"wp-image-2666\" style=\"width:1000px;height:auto\" srcset=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/SPES-cyclotron_v5.jpg 876w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/SPES-cyclotron_v5-300x75.jpg 300w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/SPES-cyclotron_v5-768x192.jpg 768w\" sizes=\"(max-width: 876px) 100vw, 876px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"has-text-align-center has-theme-palette-9-color has-theme-palette-1-background-color has-text-color has-background has-link-color wp-elements-1 wp-block-paragraph\"><strong>NEWS!<\/strong><\/p>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color has-link-color wp-elements-2 wp-block-paragraph\"><em>An important milestone has been achieved in September 2026: the radionuclide copper-67 (<em><strong>\u2076\u2077Cu<\/strong><\/em>) has been produced&nbsp;for the first time in Italy in the framework of the <a href=\"https:\/\/web.infn.it\/LARAMED\/cuprum-ttd\/\" data-type=\"page\" data-id=\"629\">CUPRUM_TTD<\/a> project, <em>funded by INFN\u2019s National Scientific Commission 5 (CSN5) and developed at the Legnaro National Laboratories<\/em>.&nbsp;<br><br>This result marks a significant milestone in a multi-year research and development effort, carried out through close collaboration among INFN, the University of Ferrara, and the IRCCS Sacro Cuore Don Calabria Hospital. Such important achievement is the result of years of experimental work, multidisciplinary expertise, and continuous collaboration among the nuclear physicists, engineers, chemists, and researchers involved in the project.<\/em><\/p>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color has-link-color wp-elements-3 wp-block-paragraph\"><em>\u2076\u2077Cu is one of the therapeutic radionuclides of greatest international interest due to its unique physical and radiobiological characteristics. Its emission of beta-minus particles allows it to be used in the treatment of various types of cancer, while the concomitant emission of \u03b3 photons enables SPECT imaging, which is useful for assessing biodistribution, monitoring therapy, and dosimetry. Its use therefore appears particularly promising in the field of personalized nuclear medicine, especially for the treatment of cancers such as prostate cancer and glioblastoma.<br><\/em><br><em>The production and purification of <strong>\u2076\u2077Cu<\/strong> following the irradiation of an enriched <strong>\u2077\u2070Zn<\/strong> target represent a significant step toward making this radionuclide available for future preclinical and clinical research, confirming the role of LNL-INFN in the development of advanced technologies and infrastructure to support nuclear medicine and biomedical applications. Additional information can be found <a href=\"https:\/\/web.infn.it\/TechTransfer\/rame-67\/\">here<\/a>. <\/em><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"733\" src=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2026\/09\/IMG_1759-1024x733.jpg\" alt=\"\" class=\"wp-image-3278\" style=\"width:1038px;height:auto\" srcset=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2026\/09\/IMG_1759-1024x733.jpg 1024w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2026\/09\/IMG_1759-1536x1099.jpg 1536w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2026\/09\/IMG_1759-2048x1466.jpg 2048w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2026\/09\/IMG_1759-500x358.jpg 500w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2026\/09\/IMG_1759-768x550.jpg 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">The enriched \u2077\u2070Zn target coin realized with the <a href=\"https:\/\/web.infn.it\/LARAMED\/sps-2\/\" data-type=\"page\" data-id=\"3186\">Spark Plasma Sintering<\/a> method.<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"has-theme-palette-1-background-color has-background wp-block-paragraph\"><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"680\" src=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2026\/03\/LARAMED-12ICI-1024x680.png\" alt=\"\" class=\"wp-image-3248\" srcset=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2026\/03\/LARAMED-12ICI-1024x680.png 1024w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2026\/03\/LARAMED-12ICI-500x332.png 500w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2026\/03\/LARAMED-12ICI-768x510.png 768w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2026\/03\/LARAMED-12ICI.png 1355w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"has-theme-palette-2-color has-text-color has-link-color wp-elements-4 wp-block-paragraph\">The LARAMED team at the 12th International Conference on Isotopes (12ICI: <a href=\"http:\/\/www.12ici.org\">www.12ici.org<\/a>), held in Florence in February 2026.<\/p>\n\n\n\n<p class=\"has-theme-palette-1-background-color has-background wp-block-paragraph\"><\/p>\n\n\n\n<h2 class=\"wp-block-heading has-medium-font-size\">\u201c<em>Nuclear for Health<\/em>\u201d: A dialog among science, business and istitutions for the health of future.<\/h2>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color has-link-color wp-elements-5 wp-block-paragraph\">Liliana Mou, a technologist of the Legnaro National Laboratories and member of the LARAMED team, restate the preeminence international role of INFN in the research on medical radionuclides:<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-wp-embed is-provider-techtransfer-infn wp-block-embed-techtransfer-infn\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"xtTLqkSxI1\"><a href=\"https:\/\/web.infn.it\/TechTransfer\/convegno-nucleare-per-la-salute-il-dialogo-tra-scienza-impresa-e-istituzioni-per-la-sanita-del-domani\/\">Convegno \u201cNucleare per la salute\u201d: il dialogo tra scienza, impresa e istituzioni per la sanit\u00e0 del domani<\/a><\/blockquote><iframe class=\"wp-embedded-content\" sandbox=\"allow-scripts\" security=\"restricted\" style=\"position: absolute; visibility: hidden;\" title=\"\u201cConvegno \u201cNucleare per la salute\u201d: il dialogo tra scienza, impresa e istituzioni per la sanit\u00e0 del domani\u201d \u2014 TechTransfer INFN\" src=\"https:\/\/web.infn.it\/TechTransfer\/convegno-nucleare-per-la-salute-il-dialogo-tra-scienza-impresa-e-istituzioni-per-la-sanita-del-domani\/embed\/#?secret=AViiQFWOXJ#?secret=xtTLqkSxI1\" data-secret=\"xtTLqkSxI1\" width=\"600\" height=\"338\" frameborder=\"0\" marginwidth=\"0\" marginheight=\"0\" scrolling=\"no\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<p class=\"has-theme-palette-1-background-color has-background wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color has-link-color wp-elements-6 wp-block-paragraph\">In the framework of the <a href=\"https:\/\/home.infn.it\/it\/\">INFN<\/a> activities dedicated to <a href=\"https:\/\/web.infn.it\/INFN4LS\/\">life science<\/a>, the <strong>LARAMED<\/strong> (LAboratory of RAdionuclides for MEDicine) project at the Legnaro National Laboratories (<a href=\"https:\/\/www.lnl.infn.it\/\">LNL<\/a>) now assumes a key role. The aim is to investigate the production methods of innovative radionuclides to be employed in diagnostic and therapeutic medical procedures, mainly for tumours, with next-generation radiopharmaceuticals. <strong>First cross section measurement tests have been successfully performed using the target station tailored designed<\/strong> (and shown in the picutre below). Several proton beam energies accelerated by the SPES cyclotron have been tested with stacked-foils target composed by thin layers of different materials. The figure below shows the gamma spectra of a natural zinc target, irradiated with 50 MeV protons, where the <strong><sup>67<\/sup>Cu<\/strong> gamma lines can be observed (highlighted in the plot). The theranostic <strong><sup>67<\/sup>Cu<\/strong> radionuclide, among the LARAMED <a href=\"https:\/\/web.infn.it\/LARAMED\/projects\/\" data-type=\"page\" data-id=\"170\">goals<\/a>, is currently under the spotlight of the international community for its potential in the diagnosis and treatment of some tumours, e.g. prostate cancer and glioblastoma.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"944\" height=\"402\" src=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/07\/spectratargte-station.png\" alt=\"\" class=\"wp-image-3085\" srcset=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/07\/spectratargte-station.png 944w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/07\/spectratargte-station-500x213.png 500w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/07\/spectratargte-station-768x327.png 768w\" sizes=\"(max-width: 944px) 100vw, 944px\" \/><figcaption class=\"wp-element-caption\">Natural zinc spectrum with <strong><sup>67<\/sup>Cu<\/strong> gamma lines highlighted (left); target station used for the first cross sections tests (right).<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"has-theme-palette-1-background-color has-background wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color has-link-color wp-elements-7 wp-block-paragraph\" style=\"font-size:18px\">The website presents the <strong>LARAMED<\/strong> (<em>LAboratory of RAdionuclides for MEDicine<\/em>) facility, as part of the <strong>SPES<\/strong> (<em>Selective Production of Exotic Species<\/em>) research <a href=\"https:\/\/web.infn.it\/LARAMED\/facility\/\" data-type=\"page\" data-id=\"166\">infrastructure<\/a> under completion at the INFN-LNL, along with the main <a href=\"https:\/\/web.infn.it\/LARAMED\/projects\/\" data-type=\"page\" data-id=\"170\">project <\/a>outcomes gained during the last years, thanks to an ongoing fruitful network of <a href=\"https:\/\/web.infn.it\/LARAMED\/collaborations\/\" data-type=\"page\" data-id=\"172\">collaborations.<\/a>&nbsp;<\/p>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color has-link-color wp-elements-8 wp-block-paragraph\" style=\"font-size:18px\">The interdisciplinary aspects of the production of medically-relevant radionuclides, such as <strong><sup>67<\/sup>Cu<\/strong>, <strong><sup>47<\/sup>Sc<\/strong>, <strong><sup>52<\/sup>Mn<\/strong> etc., are shown, including the latest <a href=\"https:\/\/web.infn.it\/LARAMED\/technology\/\" data-type=\"page\" data-id=\"168\">technological achievements<\/a> in targetry, radiochemistry, and applied nuclear physics.&nbsp;<\/p>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color has-link-color wp-elements-9 wp-block-paragraph\" style=\"font-size:18px\">The ambitious goals of the LARAMED project are reached thanks to a solid <a href=\"https:\/\/web.infn.it\/LARAMED\/team\/\" data-type=\"page\" data-id=\"185\">team<\/a> work.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"288\" src=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/INFN_Asimmetrie-LARAMED-steps.jpg\" alt=\"\" class=\"wp-image-2661\" srcset=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/INFN_Asimmetrie-LARAMED-steps.jpg 1000w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/INFN_Asimmetrie-LARAMED-steps-300x86.jpg 300w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/INFN_Asimmetrie-LARAMED-steps-768x221.jpg 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><figcaption class=\"wp-element-caption\">Scheme of the main steps in the direct production of medical radionuclides.<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"has-theme-palette-3-color has-text-color has-link-color wp-elements-10 wp-block-paragraph\">The research activities on radionuclides production for medicine (e.g., new radiopharmaceuticals development) and applied and interdisciplinary physics (e.g., radiobiology and environmental studies) at the INFN-LNL are coordinated by the <em>Radionuclides for <a href=\"https:\/\/www.lnl.infn.it\/servizio-radioisotopi-per-la-medicina-e-la-fisica-applicata\/\">Medicine and Applied Physics service <\/a>(RMFA) <\/em>located in the research division.<\/p>\n\n\n\n<ul class=\"wp-block-list has-theme-palette-3-color has-text-color has-link-color has-small-font-size wp-elements-11\">\n<li><em>More information can be found here:<\/em><\/li>\n\n\n\n<li>G. Pupillo, A. Andrighetto, A. Arzenton, M. Ballan, M. Bello, A. Boschi, S. Cisternino, S. Corradetti, L. De Dominicis, J. Esposito, E. Fioretto, T. Ghirardi, M. Manzolaro, E. Mariotti, P. Martini, L. Melendez-Alafort, A. Monetti, L. Mou, D. Scarpa, G. Sciacca, D. Serafini, Cyclotron-based production of innovative medical radionuclides at the INFN-LNL: state of the art and perspective, The European Physical Journal Plus (2023) DOI: 10.1140\/epjp\/s13360-023-04564-3 <a href=\"https:\/\/link.springer.com\/article\/10.1140\/epjp\/s13360-023-04564-3\">https:\/\/link.springer.com\/article\/10.1140\/epjp\/s13360-023-04564-3<\/a><\/li>\n\n\n\n<li>G. Pupillo, A. Boschi, S. Cisternino, L. De Dominicis, P. Martini, L. Mou, C. Rossi Alvarez, G. Sciacca, J. Esposito, The LARAMED project at INFN\u2011LNL: review of the research activities on medical radionuclides production with the SPES cyclotron, Journal of Radioanalytical and Nuclear Chemistry (2023) DOI: 10.1007\/s10967-023-09075-0 <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s10967-023-09075-0?utm_source=xmol&amp;utm_medium=affiliate&amp;utm_content=meta&amp;utm_campaign=DDCN_1_GL01_metadata\">https:\/\/link.springer.com\/article\/10.1007\/s10967-023-09075-0?utm_source=xmol&amp;utm_medium=affiliate&amp;utm_content=meta&amp;utm_campaign=DDCN_1_GL01_metadata<\/a><\/li>\n\n\n\n<li>L. Mou, &#8220;La ricerca sui radiofarmaci&#8221;, Approfondimento in Asimmetrie 35 Applicazioni, INFN <a href=\"https:\/\/www.asimmetrie.it\/curare-con-le-particelle?highlight=WyJtb3UiXQ%3D%3D&amp;fbclid=IwAR0X1A5E6JoZga2dGZPd7mJ2Rpv1oLGZUZC9Tudhtprk7z-GxGrsKkscSwc \">https:\/\/www.asimmetrie.it\/curare-con-le-particelle?highlight=WyJtb3UiXQ%3D%3D&amp;fbclid=IwAR0X1A5E6JoZga2dGZPd7mJ2Rpv1oLGZUZC9Tudhtprk7z-GxGrsKkscSwc <\/a><\/li>\n\n\n\n<li>M. Ballan et al., Nuclear physics mid term plan at Legnaro National Laboratories (LNL), Eur. Phys. J. Plus 138, 709 (2023) DOI: 10.1140\/epjp\/s13360-023-04249-x2023 <a href=\"https:\/\/link.springer.com\/article\/10.1140\/epjp\/s13360-023-04249-x\">https:\/\/link.springer.com\/article\/10.1140\/epjp\/s13360-023-04249-x<\/a><\/li>\n\n\n\n<li>G. Pupillo, P. Antonini, M. Calderolla, A. Calore, D. Bettoni, A. Boschi, S. Cisternino, A. Duatti, F. Evangelisti, P. Favaron, G. Fiorentini, F. Gramegna, G. Keppel, M. Maggiore, P. Martini, L. Mou, M. Pasquali, L. Pranovi, C. Rossi Alvarez, L. Sarchiapone, G. Sciacca, H. Skliarova and J. Esposito, The Laramed Project at LNL: <sup>67<\/sup>Cu and<sup> 47<\/sup>Sc Production for Theranostic Applications, AIP Conference Proceedings 2295, 020001 (2020); DOI: 10.1063\/5.0032898 <a href=\"https:\/\/pubs.aip.org\/aip\/acp\/article-abstract\/2295\/1\/020001\/747692\/The-Laramed-project-at-LNL-67Cu-and-47Sc?redirectedFrom=fulltext\">https:\/\/pubs.aip.org\/aip\/acp\/article-abstract\/2295\/1\/020001\/747692\/The-Laramed-project-at-LNL-67Cu-and-47Sc?redirectedFrom=fulltext<\/a><\/li>\n\n\n\n<li>J. Esposito, D. Bettoni, A. Boschi, M. Calderolla, S. Cisternino, G. Fiorentini, G. Keppel, P. Martini, M. Maggiore, L. Mou, M. Pasquali, L. Pranovi, G. Pupillo, C. Rossi Alvarez, L. Sarchiapone, G. Sciacca, H. Skliarova, P. Favaron, A. Lombardi, P. Antonini, A. Duatti, LARAMED: a LAboratory for Radionuclides of MEDical interest; Molecules; 2019, 24(1), 20 DOI: 10.3390\/molecules24010020 <a href=\"https:\/\/www.mdpi.com\/1420-3049\/24\/1\/20\">https:\/\/www.mdpi.com\/1420-3049\/24\/1\/20<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>NEWS! An important milestone has been achieved in September 2026: the radionuclide copper-67 (\u2076\u2077Cu) has been produced&nbsp;for the first time in Italy in the framework of the CUPRUM_TTD project, funded by INFN\u2019s National Scientific Commission 5 (CSN5) and developed at the Legnaro National Laboratories.&nbsp; This result marks a significant milestone in a multi-year research and&#8230;<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_themeisle_gutenberg_block_has_review":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"normal","_kad_post_sidebar_id":"","_kad_post_content_style":"default","_kad_post_vertical_padding":"top","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-1893","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages\/1893","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/comments?post=1893"}],"version-history":[{"count":32,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages\/1893\/revisions"}],"predecessor-version":[{"id":3289,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages\/1893\/revisions\/3289"}],"wp:attachment":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/media?parent=1893"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}