{"id":625,"date":"2023-02-22T16:15:22","date_gmt":"2023-02-22T15:15:22","guid":{"rendered":"http:\/\/localhost:8888\/progetti\/laramed\/?page_id=625"},"modified":"2024-02-14T15:09:14","modified_gmt":"2024-02-14T14:09:14","slug":"apotematechn-osp","status":"publish","type":"page","link":"https:\/\/web.infn.it\/LARAMED\/apotematechn-osp\/","title":{"rendered":"Apotema"},"content":{"rendered":"<style>.wp-block-kadence-advancedheading.kt-adv-heading625_822597-ec, .wp-block-kadence-advancedheading.kt-adv-heading625_822597-ec[data-kb-block=\"kb-adv-heading625_822597-ec\"]{text-align:center;font-size:var(--global-kb-font-size-md, 1.25rem);font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading625_822597-ec mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading625_822597-ec[data-kb-block=\"kb-adv-heading625_822597-ec\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading625_822597-ec img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading625_822597-ec[data-kb-block=\"kb-adv-heading625_822597-ec\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading625_822597-ec wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading625_822597-ec\"><strong>APOTEMA (INFN-CSN5, 2012-2014)<br>TECHN-OSP (INFN-CSN5, 2015-2017)<\/strong><\/h2>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color has-link-color wp-elements-66dacd8131ebfa1113049b8e784df407\">APOTEMA and TECHNOSP are acronyms for <em>Accelerator-based Production Of TEchnetium\/Molybdenum for medical Applications<\/em> and <em>TECHNetium direct-production in hOSPital<\/em>, respectively. The first radioisotope we started working on was indeed the <strong><sup>99m<\/sup>Tc<\/strong>. The purpose of this work was the development of a technology able to produce 1\u20132 Ci amount of <strong><sup>99m<\/sup>Tc<\/strong> by low-energy cyclotron in a local nuclear medicine radiopharmacy and to prove its feasibility.&nbsp;<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"516\" src=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/12\/Apotema_v2-1024x516.png\" alt=\"\" class=\"wp-image-2096\" style=\"width:861px;height:auto\" srcset=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/12\/Apotema_v2-1024x516.png 1024w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/12\/Apotema_v2-1536x774.png 1536w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/12\/Apotema_v2-2048x1033.png 2048w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/12\/Apotema_v2-300x151.png 300w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/12\/Apotema_v2-768x387.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Main steps in the development of a technology to produce GBq amount of <strong><sup>99m<\/sup>Tc<\/strong><\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"has-theme-palette-3-color has-text-color has-link-color wp-elements-fda7ab25fa699857a855d18a428bcd28\">We investigated the <strong><sup>99m<\/sup>Tc<\/strong> direct cyclotron production route by the (<em>p<\/em>,2<em>n<\/em>) reaction on an isotopically enriched <strong><sup>100<\/sup>Mo<\/strong> target. The irradiation parameters were optimised for an in-hospital cyclotron self-production of <strong><sup>99m<\/sup>Tc<\/strong> able to satisfy the needs of a medium-large hospital such as the <a href=\"https:\/\/www.aosp.bo.it\/\" data-type=\"page\" data-id=\"172\">Policlinico Sant\u2019Orsola Malpighi<\/a>, to afford its availability in case of shortages.<br>This is the most complete project in which we developed all the <a href=\"https:\/\/web.infn.it\/LARAMED\/technology\/\" data-type=\"page\" data-id=\"168\">technologies<\/a> necessary to complete the entire production cycle from the target to a solvent extraction-based automatic separation and purification module, including the target recovery and radiopharmaceutical and preclinical studies.&nbsp;<br>With these two projects, the LARAMED group has also contributed to the international <a href=\"https:\/\/www.iaea.org\/newscenter\/news\/crp-success-story-f22062-accelerator-based-alternatives-to-non-heu-production-of-mo-99\/tc-99m-2011-2015\">IAEA Coordinated Research Project (CRP) No. F22062<\/a> focused on <em>Alternative, non HEU-based, <\/em><strong><sup>99<em>m<\/em><\/sup>Tc\/ <sup>99<em>m<\/em><\/sup>Mo<\/strong> supply (2011\u20132015).<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p> <\/p>\n\n\n\n<ul class=\"has-theme-palette-3-color has-text-color has-link-color has-small-font-size wp-block-list wp-elements-af1090a6005fa41c6acd4ae00579cbe3\">\n<li><em>More information can be found here:<\/em><\/li>\n\n\n\n<li>N. Uzunov, L. Melendez-Alafort, M. Bello, G. Cicoria, F. Zagni, L. De Nardo, A. Selva, L. Mou, C. Rossi Alvarez, G. Pupillo, G. Di Domenico, L. Uccelli, A. Boschi, F. Groppi, A. Salvini, A. Taibi, A. Duatti, P. Martini, M. Pasquali, M. Loriggiola, M. Marengo, L. Strada, S. Manenti, A. Rosato and J. Esposito, Radioisotopic purity and imaging properties of cyclotron-produced <sup>99m<\/sup>Tc using direct <sup>100<\/sup>Mo(p,2n) reaction (2018) Physics in Medicine and Biology 63, 185021 DOI: 10.1088\/ 1361-6560\/aadc88 <a href=\"https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/aadc88\">https:\/\/iopscience.iop.org\/article\/10.1088\/1361-6560\/aadc88<\/a><\/li>\n\n\n\n<li>P. Martini, A. Boschi, G. Cicoria, F. Zagni, A. Corazza, L. Uccelli, M. Pasquali, G. Pupillo, M. Marengo, M. Loriggiola, H. Skliarova, L. Mou, S. Cisternino, S. M. Carturan, L. Melendez Alafort, N. M. Uzunov, M. Bello, C. Rossi Alvarez, J. Esposito, A. Duatti (2018) In-house Cyclotron Production of High-purity Tc-99m and Tc-99m Radiopharmaceuticals, Applied Radiation and Isotopes, DOI:10.1016\/j.apradiso.2018.05.033<a href=\" https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0969804317312125\"> https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0969804317312125<\/a><\/li>\n\n\n\n<li>P. Martini, A. Boschi, G. Cicoria, L. Uccelli, M. Pasquali, A. Duatti, G. Pupillo, M. Marengo, M. Loriggiola, J. Esposito (2016) A solvent-extraction module for cyclotron production of high-purity technetium-99m, Applied Radiation and Isotopes, DOI:10.1016\/j.apradiso.2016.10.002 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27744212\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/27744212\/<\/a><\/li>\n\n\n\n<li>G. Pupillo, J. Esposito, F. Haddad, N. Michel, M. Gambaccini (2015) Accelerator-based production of <sup>99<\/sup>Mo: A comparison between the <sup>100<\/sup>Mo(p,x) and <sup>96<\/sup>Zr(a,n) reaction, Journal of Radioanalitical and Nuclear Chemistry, DOI: 10.1007\/s10967-015-4091-8 <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s10967-015-4091-8\">https:\/\/link.springer.com\/article\/10.1007\/s10967-015-4091-8<\/a><\/li>\n\n\n\n<li>G. Pupillo, J. Esposito, M. Gambaccini, F. Haddad, N. Michel (2014) Experimental Cross Section Evaluation For Innovative <sup>99<\/sup>Mo Production via the (a,n) Reaction on <sup>96<\/sup>Zr Target, Journal of Radioanalitical and Nuclear Chemistry, DOI: 10.1007\/s10967-014-3321-9 <a href=\"https:\/\/link.springer.com\/article\/10.1007\/s10967-014-3321-9\">https:\/\/link.springer.com\/article\/10.1007\/s10967-014-3321-9<\/a><\/li>\n\n\n\n<li>S. Manenti, U. Holzwarth, M. Loriggiola, L. Gini, J. Esposito, F. Groppi, F. Simonelli, The excitation functions of <sup>100<\/sup>Mo(p,x)<sup>99<\/sup>Mo and <sup>100<\/sup>Mo(p,2n)<sup>99m<\/sup>Tc, Applied Radiation and Isotopes, 94 (2014) 344-348, <a href=\"https:\/\/doi.org\/10.1016\/j.apradiso.2014.09.010.\">https:\/\/doi.org\/10.1016\/j.apradiso.2014.09.010<\/a><\/li>\n\n\n\n<li>J. Esposito, G. Vecchi, G. Pupillo, A. Taibi, L. Uccelli, A. Boschi, M. Gambaccini (2013) Evaluation of <sup>99<\/sup>Mo and <sup>99m<\/sup>Tc Productions Based on a High-Performance Cyclotron, Science and Technology of Nuclear Installations, Article ID 972381, ISSN: 1687-6083, DOI:10.1155\/2013\/972381<a href=\" https:\/\/www.hindawi.com\/journals\/stni\/2013\/972381\/\"> https:\/\/www.hindawi.com\/journals\/stni\/2013\/972381\/<\/a><\/li>\n\n\n\n<li>L. Uccelli, A. Boschi, M. Pasquali, A. Duatti, G. Di Domenico, G. Pupillo, J. Esposito, M. Giganti, A. Taibi, M. Gambaccini (2013) Influence of the Generator in-Growth Time on the Final Radiochemical Purity and Stability of <sup>99m<\/sup>Tc Radiopharmaceuticals, Science and Technology of Nuclear Installations, Article ID 379283, ISSN: 1687-6083, DOI: 10.1155\/2013\/379283 <a href=\"https:\/\/www.hindawi.com\/journals\/stni\/2013\/379283\/\">https:\/\/www.hindawi.com\/journals\/stni\/2013\/379283\/<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>APOTEMA (INFN-CSN5, 2012-2014)TECHN-OSP (INFN-CSN5, 2015-2017) APOTEMA and TECHNOSP are acronyms for Accelerator-based Production Of TEchnetium\/Molybdenum for medical Applications and TECHNetium direct-production in hOSPital, respectively. The first radioisotope we started working on was indeed the 99mTc. The purpose of this work was the development of a technology able to produce 1\u20132 Ci amount of 99mTc by&#8230;<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_themeisle_gutenberg_block_has_review":false,"_kad_post_transparent":"disable","_kad_post_title":"hide","_kad_post_layout":"left","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-625","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages\/625","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/comments?post=625"}],"version-history":[{"count":5,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages\/625\/revisions"}],"predecessor-version":[{"id":2727,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages\/625\/revisions\/2727"}],"wp:attachment":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/media?parent=625"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}