{"id":628,"date":"2023-02-22T16:03:25","date_gmt":"2023-02-22T15:03:25","guid":{"rendered":"http:\/\/localhost:8888\/progetti\/laramed\/?page_id=628"},"modified":"2024-02-26T18:18:45","modified_gmt":"2024-02-26T17:18:45","slug":"metrics","status":"publish","type":"page","link":"https:\/\/web.infn.it\/LARAMED\/metrics\/","title":{"rendered":"Metrics"},"content":{"rendered":"<style>.wp-block-kadence-advancedheading.kt-adv-heading628_12fd11-42, .wp-block-kadence-advancedheading.kt-adv-heading628_12fd11-42[data-kb-block=\"kb-adv-heading628_12fd11-42\"]{text-align:center;font-size:var(--global-kb-font-size-md, 1.25rem);font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading628_12fd11-42 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading628_12fd11-42[data-kb-block=\"kb-adv-heading628_12fd11-42\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading628_12fd11-42 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading628_12fd11-42[data-kb-block=\"kb-adv-heading628_12fd11-42\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading628_12fd11-42 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading628_12fd11-42\"><strong>METRICS (INFN-CSN5, 2018-2021)<\/strong><\/h2>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color has-link-color wp-elements-1fd714cb87a930092616e0159fbe339a\">METRICS project, acronym for <em>Multimodal pET\/mRi Imaging with Cyclotron-produced <\/em><sup>52\/51<\/sup>Mn<em> iSotopes<\/em>, was dedicated to <strong><sup>52<\/sup>Mn<\/strong> accelerator-based production and to the development of innovative radiopharmaceuticals for PET\/MRI dual-imaging purposes.&nbsp;<\/p>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color has-link-color wp-elements-4e7ba0b60ba03ba6312af6d7079afdbd\">To establish the potential of radioactive manganese chloride as a safe clinical PET imaging agent, the radiation effective dose of both <strong><sup>51<\/sup>Mn<\/strong> and <strong><sup>52<\/sup>Mn<\/strong> chloride has been assessed with the OLINDA code, in collaboration with experts in dosimetric studies (<a href=\"https:\/\/www.ioveneto.it\/\">IOV<\/a> and <a href=\"https:\/\/www.unipd.it\/\">Padova<\/a>). Simulations were carried out to compare the amount of activity and radionuclidic purity of <strong><sup>52g<\/sup>Mn<\/strong> produced by different reactions as well as the dose increase to the patient caused by the radioactive contaminants co-produced by each reaction.&nbsp;<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"832\" height=\"598\" src=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/07\/image-19.png\" alt=\"\" class=\"wp-image-1458\" style=\"width:408px;height:293px\" srcset=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/07\/image-19.png 832w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/07\/image-19-300x216.png 300w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/07\/image-19-768x552.png 768w\" sizes=\"(max-width: 832px) 100vw, 832px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"has-text-align-left has-theme-palette-3-color has-text-color\">Different <strong>Cr <\/strong>target configurations have been studied using the <a href=\"https:\/\/web.infn.it\/LARAMED\/sps\/\" data-type=\"page\" data-id=\"1807\">SPS technique<\/a> starting from <strong><sup>nat<\/sup>Cr<\/strong> and <strong><sup>52<\/sup>Cr<\/strong> powder. After the sintering of the <strong>Cr<\/strong> pellet, its adhesion to the backing support (Au\/Cu, Nb or Au\/Nb) was carried out by SPS process. The obtained targets have been successfully tested at 50 \u03bcA (energy 19 MeV and 16 MeV), the maximum current available in the medical cyclotron of the <a href=\"https:\/\/www.sacrocuore.it\" data-type=\"page\" data-id=\"172\">Sacro Cuore Don Calabria<\/a> hospital.&nbsp;<\/p>\n\n\n\n<p class=\"has-text-align-left has-theme-palette-3-color has-text-color\">A dedicated dissolution reactor was developed to dissolve the solid targets after irradiation to process the produced radioisotope with automatic modules, as betetr optimized during the <a href=\"https:\/\/web.infn.it\/LARAMED\/stardis\/\" data-type=\"page\" data-id=\"2191\">STARDIS<\/a> project. Within this project, we recently investigated a new class of <strong>Mn(II)<\/strong> complexes to be potentially used as MRI contrast media and in particular the synthesis, characterization and evaluation of magnetic properties by phantom image studies of the new [<strong>Mn(II)<\/strong>(1.4-dioxa-8-azaspiro[4.5]decane-8-carbodithioate)2]\u00b72 H<sub>2<\/sub>O compound potentially useful as MRI contrast agent, in collaboration with the <a href=\"https:\/\/www.unife.it\">Ferrara University<\/a>  Radiochemistry, radiopharmacy and preclinical imaging<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"481\" height=\"398\" src=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/12\/Metrics_v2.png\" alt=\"Example of Cr Target and reactor prototype\" class=\"wp-image-2156\" style=\"width:521px;height:323px\" srcset=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/12\/Metrics_v2.png 481w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/12\/Metrics_v2-300x248.png 300w\" sizes=\"(max-width: 481px) 100vw, 481px\" \/><figcaption class=\"wp-element-caption\"><strong>a<\/strong> Example of the <strong>Cr<\/strong> target realized by the SPS technique: <strong>Cr<\/strong> pellet on Au\/Nb backing and <strong>b <\/strong>the reactor protype under development mounted on an Eckert and Ziegler module.<\/figcaption><\/figure>\n<\/div>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>METRICS (INFN-CSN5, 2018-2021) METRICS project, acronym for Multimodal pET\/mRi Imaging with Cyclotron-produced 52\/51Mn iSotopes, was dedicated to 52Mn accelerator-based production and to the development of innovative radiopharmaceuticals for PET\/MRI dual-imaging purposes.&nbsp; To establish the potential of radioactive manganese chloride as a safe clinical PET imaging agent, the radiation effective dose of both 51Mn and 52Mn&#8230;<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_themeisle_gutenberg_block_has_review":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-628","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages\/628","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/comments?post=628"}],"version-history":[{"count":2,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages\/628\/revisions"}],"predecessor-version":[{"id":2838,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages\/628\/revisions\/2838"}],"wp:attachment":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/media?parent=628"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}