{"id":631,"date":"2023-02-14T11:14:26","date_gmt":"2023-02-14T10:14:26","guid":{"rendered":"http:\/\/localhost:8888\/progetti\/laramed\/?page_id=631"},"modified":"2024-03-28T11:41:52","modified_gmt":"2024-03-28T10:41:52","slug":"come","status":"publish","type":"page","link":"https:\/\/web.infn.it\/LARAMED\/come\/","title":{"rendered":"Come"},"content":{"rendered":"<style>.wp-block-kadence-advancedheading.kt-adv-heading631_db7bb3-a3, .wp-block-kadence-advancedheading.kt-adv-heading631_db7bb3-a3[data-kb-block=\"kb-adv-heading631_db7bb3-a3\"]{text-align:center;font-size:var(--global-kb-font-size-md, 1.25rem);font-style:normal;}.wp-block-kadence-advancedheading.kt-adv-heading631_db7bb3-a3 mark.kt-highlight, .wp-block-kadence-advancedheading.kt-adv-heading631_db7bb3-a3[data-kb-block=\"kb-adv-heading631_db7bb3-a3\"] mark.kt-highlight{font-style:normal;color:#f76a0c;-webkit-box-decoration-break:clone;box-decoration-break:clone;padding-top:0px;padding-right:0px;padding-bottom:0px;padding-left:0px;}.wp-block-kadence-advancedheading.kt-adv-heading631_db7bb3-a3 img.kb-inline-image, .wp-block-kadence-advancedheading.kt-adv-heading631_db7bb3-a3[data-kb-block=\"kb-adv-heading631_db7bb3-a3\"] img.kb-inline-image{width:150px;vertical-align:baseline;}<\/style>\n<h2 class=\"kt-adv-heading631_db7bb3-a3 wp-block-kadence-advancedheading\" data-kb-block=\"kb-adv-heading631_db7bb3-a3\"><strong>COME  (INFN-CSN3, 2016)<\/strong><\/h2>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color has-link-color wp-elements-bfb1f0d9382a339a904197a2bc2f5e18\">COME, acronym for <em>COpper MEasurement<\/em>, was a 1-year project, dedicated to the first measurements of the <strong><sup>70<\/sup>Zn<\/strong>(<em>p<\/em>,<em>x<\/em>)<strong><sup>67,64<\/sup>Cu<\/strong> nuclear reactions above 35 MeV, performed in collaboration with the <a href=\"https:\/\/www.arronax-nantes.fr\/en\/\">ARRONAX facility<\/a> (Saint-Herblain, France<a href=\"https:\/\/www.arronax-nantes.fr\/en\/\">)<\/a>.<\/p>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color\"><strong><sup>67<\/sup>Cu<\/strong> is an emerging radionuclide, under the spotlight of the scientific community, thanks to its decay characteristics. The <strong><sup>67<\/sup>Cu<\/strong> half-life (T<sub>1<em>\/<\/em>2<\/sub> 61.9 h) allows for labeling pharmaceuticals having slow pharmacokinetics, while <em>\u03b2<\/em><sup>\u2212<\/sup>\/<em>\u03b3 <\/em>radiation (for <strong><sup>67<\/sup>Cu<\/strong>) and <em>\u03b2<\/em><sup>\u2212<\/sup>\/<em>\u03b2<\/em><sup>+<\/sup> emission (for <strong><sup>64<\/sup>Cu<\/strong>,T<sub>1<em>\/<\/em>2<\/sub> 12.7 h) are suitable for therapy and SPECT\/PET imaging, respectively.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"618\" height=\"1024\" src=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/COME_radiochemistry-618x1024.jpg\" alt=\"\" class=\"wp-image-2633\" style=\"width:403px;height:auto\" srcset=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/COME_radiochemistry-618x1024.jpg 618w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/COME_radiochemistry-181x300.jpg 181w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/COME_radiochemistry-768x1272.jpg 768w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/COME_radiochemistry-928x1536.jpg 928w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/COME_radiochemistry.jpg 1098w\" sizes=\"(max-width: 618px) 100vw, 618px\" \/><figcaption class=\"wp-element-caption\">Main steps of the radiochemical separation process developed and optimized in collaboration with the <a href=\"https:\/\/web.infn.it\/LARAMED\/collaborations\/\" data-type=\"page\" data-id=\"172\">Ferrara University<\/a> and the <a href=\"https:\/\/web.infn.it\/LARAMED\/collaborations\/\" data-type=\"page\" data-id=\"172\">Sant&#8217;Orsola hospital<\/a> in Bologna.<\/figcaption><\/figure>\n<\/div>\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"309\" src=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/COME_67-64Cu_xs-1024x309.png\" alt=\"\" class=\"wp-image-2635\" srcset=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/COME_67-64Cu_xs-1024x309.png 1024w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/COME_67-64Cu_xs-300x90.png 300w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/COME_67-64Cu_xs-768x232.png 768w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/COME_67-64Cu_xs-1536x463.png 1536w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2024\/02\/COME_67-64Cu_xs-2048x618.png 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Measurement of the nuclear reactions&nbsp; <strong><sup>70<\/sup>Zn<\/strong>(<em>p<\/em>,<em>x<\/em>)<strong><sup>67,64<\/sup>Cu<\/strong> carried out within the COME project.<\/figcaption><\/figure>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\"><div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"909\" height=\"538\" src=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/12\/Immagine_XS-ratio_COME.bmp\" alt=\"Plot of the nuclear cross section ratio for the production of 67Cu and 64Cu radionuclides\" class=\"wp-image-2132\" style=\"width:613px;height:auto\" srcset=\"https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/12\/Immagine_XS-ratio_COME.bmp 909w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/12\/Immagine_XS-ratio_COME-300x178.bmp 300w, https:\/\/web.infn.it\/LARAMED\/wp-content\/uploads\/2023\/12\/Immagine_XS-ratio_COME-768x455.bmp 768w\" sizes=\"(max-width: 909px) 100vw, 909px\" \/><figcaption class=\"wp-element-caption\">Plot of the nuclear cross section ratio for the production of <strong><sup>67<\/sup>Cu<\/strong> and <strong><sup>64<\/sup>Cu<\/strong> radionuclides:<br>the continuous line is the IAEA recommended value for <strong><sup>68<\/sup>Zn<\/strong> targets; the dashed line refers to the measured values for <strong><sup>70<\/sup>Zn<\/strong> targets. The vertical dashed lines refer to the favorable energy range for <strong><sup>67<\/sup>Cu<\/strong> production. A scheme of the multi-layer target configuration described in the international <a href=\"https:\/\/web.infn.it\/LARAMED\/patents\/\" data-type=\"page\" data-id=\"181\">INFN patent<\/a> is also shown at the bottom<br><\/figcaption><\/figure>\n<\/div><\/div>\n<\/div>\n\n\n\n<p class=\"has-theme-palette-3-color has-text-color has-link-color wp-elements-12d754be70f870e0c14baefcf4540c4a\">As shown in the Figures, the <strong><sup>70<\/sup>Zn<\/strong>(<em>p<\/em>,<em>x<\/em>)<strong><sup>67,64<\/sup>Cu<\/strong> cross section results were the ground for an <a href=\"https:\/\/web.infn.it\/LARAMED\/patents\/\" data-type=\"page\" data-id=\"181\">INFN patent<\/a> on a multi-layer target to optimize <strong><sup>67<\/sup>Cu<\/strong> production exploiting a 70-MeV proton beam and enriched <strong><sup>70<\/sup>Zn<\/strong> and <strong><sup>68<\/sup>Zn<\/strong> targets, entitled &#8220;A method and a target for the production of <strong><sup>67<\/sup>Cu<\/strong>\u201d.<\/p>\n\n\n\n<ul class=\"has-theme-palette-3-color has-text-color has-link-color has-small-font-size wp-block-list wp-elements-4457e3283ed2f3f197fab57f21a5fd92\">\n<li><em>More information can be found here:<\/em><\/li>\n\n\n\n<li>L. Mou, P. Martini, G. Pupillo, I. Cieszykowska, C.S. Cutler and R. Miko\u0142ajczak, <sup>67<\/sup>Cu production capabilities: a mini review 2022 Molecules DOI: 10.3390\/molecules27051501 <a href=\"https:\/\/www.mdpi.com\/1420-3049\/27\/5\/1501\">https:\/\/www.mdpi.com\/1420-3049\/27\/5\/1501<\/a><\/li>\n\n\n\n<li>G. Pupillo, L. Mou, S. Manenti, F. Groppi, J. Esposito and F. Haddad, Nuclear data for light charged particle induced production of emerging medical radionuclides 2022 Radiochimica Acta DOI: 10.1515\/ract-2022-0011 (invited article for the Jubilee issue) <a href=\"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/ract-2022-0011\/html\">https:\/\/www.degruyter.com\/document\/doi\/10.1515\/ract-2022-0011\/html<\/a><\/li>\n\n\n\n<li>A.R. Jalilian, M.A. Gizawy, C. Alliot, S. Takacs, S. Chakarborty, M.R. Aboudzadeh Rovais, G. Pupillo et al.,IAEA Activities on <sup>67<\/sup>Cu, <sup>186<\/sup>Re, <sup>47<\/sup>Sc Theranostic radionuclides and Radiopharmaceuticals in <a>Current Radiopharmaceuticals (2021) DOI:10.2174\/1874471013999200928162322<\/a> <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32988359\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/32988359\/<\/a><\/li>\n\n\n\n<li>G. Pupillo<strong>, <\/strong>P. Antonini, M. Calderolla, A. Calore, D. Bettoni, A. Boschi, S. Cisternino, A. Duatti, F. Evangelisti, P. Favaron, G. Fiorentini, F. Gramegna, G. Keppel, M. Maggiore, P. Martini, L. Mou, M. Pasquali, L. Pranovi, C. Rossi Alvarez, L. Sarchiapone, G. Sciacca, H. Skliarova and J. Esposito, The Laramed Project at LNL: <sup>67<\/sup>Cu and <sup>47<\/sup>Sc Production for Theranostic Applications, AIP Conference Proceedings 2295, 020001 (2020); DOI: 10.1063\/5.0032898 <a href=\"https:\/\/pubs.aip.org\/aip\/acp\/article-abstract\/2295\/1\/020001\/747692\/The-Laramed-project-at-LNL-67Cu-and-47Sc?redirectedFrom=fulltext\">https:\/\/pubs.aip.org\/aip\/acp\/article-abstract\/2295\/1\/020001\/747692\/The-Laramed-project-at-LNL-67Cu-and-47Sc?redirectedFrom=fulltext<\/a><\/li>\n\n\n\n<li><a>G. Pupillo, L. Mou, P. Martini, M. Pasquali, A. Boschi, G. Cicoria, A. Duatti, F. Haddad and J. Esposito, Production of <sup>67<\/sup>Cu by enriched <sup>70<\/sup>Zn targets: first measurements of formation cross <\/a>sections of <sup>67<\/sup>Cu, <sup>64<\/sup>Cu, <sup>67<\/sup>Ga, <sup>66<\/sup>Ga,<sup> 69m<\/sup>Zn and <sup>65<\/sup>Zn in interactions of <sup>70<\/sup>Zn with protons above 45 MeV <a>Radiochimica Acta(2020) DOI: 10.1515\/ract-2019-3199<\/a> <a href=\"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/ract-2019-3199\/html\">https:\/\/www.degruyter.com\/document\/doi\/10.1515\/ract-2019-3199\/html<\/a><\/li>\n\n\n\n<li>G. Pupillo, T. Sounalet, N. Michel, L. Mou, J. Esposito, F. Haddad, New production cross sections for the theranostic radionuclide <sup>67<\/sup>Cu (2018) Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms &#8211; Volume 415, Pages 41-47 DOI: 10.1016\/j.nimb.2017.10.022  <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0168583X17309412\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0168583X17309412<\/a><\/li>\n<\/ul>\n\n\n\n<p> <\/p>\n","protected":false},"excerpt":{"rendered":"<p>COME (INFN-CSN3, 2016) COME, acronym for COpper MEasurement, was a 1-year project, dedicated to the first measurements of the 70Zn(p,x)67,64Cu nuclear reactions above 35 MeV, performed in collaboration with the ARRONAX facility (Saint-Herblain, France). 67Cu is an emerging radionuclide, under the spotlight of the scientific community, thanks to its decay characteristics. The 67Cu half-life (T1\/2&#8230;<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_themeisle_gutenberg_block_has_review":false,"_kad_post_transparent":"","_kad_post_title":"hide","_kad_post_layout":"left","_kad_post_sidebar_id":"sidebar-primary","_kad_post_content_style":"","_kad_post_vertical_padding":"top","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-631","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages\/631","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/comments?post=631"}],"version-history":[{"count":11,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages\/631\/revisions"}],"predecessor-version":[{"id":3011,"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/pages\/631\/revisions\/3011"}],"wp:attachment":[{"href":"https:\/\/web.infn.it\/LARAMED\/wp-json\/wp\/v2\/media?parent=631"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}