{"id":4345,"date":"2025-05-05T14:33:54","date_gmt":"2025-05-05T12:33:54","guid":{"rendered":"https:\/\/web.infn.it\/TechTransfer\/portfolio_page\/method-for-identifying-protein-folding-intermediates\/"},"modified":"2026-01-15T14:11:25","modified_gmt":"2026-01-15T13:11:25","slug":"method-for-identifying-protein-folding-intermediates","status":"publish","type":"portfolio_page","link":"https:\/\/web.infn.it\/TechTransfer\/en\/portfolio_page\/method-for-identifying-protein-folding-intermediates\/","title":{"rendered":"Method for identifying protein folding intermediates"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row css_animation=&#8221;&#8221; row_type=&#8221;row&#8221; use_row_as_full_screen_section=&#8221;no&#8221; type=&#8221;full_width&#8221; angled_section=&#8221;no&#8221; text_align=&#8221;left&#8221; background_image_as_pattern=&#8221;without_pattern&#8221;][vc_column][vc_raw_html]W3dwc2VvX2JyZWFkY3J1bWJd[\/vc_raw_html][vc_empty_space][vc_column_text]<\/p>\n<h1>Method for identifying protein folding intermediates<\/h1>\n<p>[\/vc_column_text][vc_empty_space][\/vc_column][\/vc_row][vc_row css_animation=&#8221;&#8221; row_type=&#8221;row&#8221; use_row_as_full_screen_section=&#8221;no&#8221; type=&#8221;full_width&#8221; angled_section=&#8221;no&#8221; text_align=&#8221;left&#8221; background_image_as_pattern=&#8221;without_pattern&#8221;][vc_column width=&#8221;2\/3&#8243;][vc_empty_space][vc_column_text]The present technology concerns a computational method for the identification of protein folding intermediates, potentially useful as targets in drug discovery processes.[\/vc_column_text][vc_empty_space][vc_single_image image=&#8221;4346&#8243; img_size=&#8221;full&#8221; qode_css_animation=&#8221;&#8221;][vc_empty_space][vc_column_text]<\/p>\n<h3><span style=\"color: #20415c;\">How does it work?<\/span><\/h3>\n<p>[\/vc_column_text][vc_empty_space][vc_column_text]Understanding how and why proteins fold into a specific conformation, as well as how the folding pathway is encoded in their sequence and structure, is of fundamental importance for the study of protein structure and design, folding and misfolding, biological regulation and function, clinical implications and industrial applications. <br \/>\nThe patented method demonstrated that a new computational approach, capable of identifying significant pathways in the protein folding process, is effective in identifying structural intermediates of proteins of pharmacological interest, opening up new perspectives for the development of drugs directed against hitherto unexplored targets.[\/vc_column_text][vc_empty_space][vc_column_text]<\/p>\n<h3><span style=\"color: #20415c;\">Applications<\/span><\/h3>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<ul>\n<li>Drug discovery;<\/li>\n<li>Pharmacology;<\/li>\n<li>Biotechnology;<\/li>\n<li>Academic and industrial research.<\/li>\n<\/ul>\n<p>[\/vc_column_text][vc_empty_space][vc_column_text]<\/p>\n<h3><span style=\"color: #20415c;\">Advantages<\/span><\/h3>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<ul>\n<li>Innovation in pharmacological targets;<\/li>\n<li>Reduction of search time and costs;<\/li>\n<li>Cross-applicability.<\/li>\n<\/ul>\n<p>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/4&#8243; css=&#8221;.vc_custom_1702567488600{margin-bottom: 50px !important;background-color: #042a48 !important;}&#8221; el_class=&#8221;.column_details_portfolio&#8221;][vc_column_text]<\/p>\n<h4><span style=\"color: #ffffff;\">ADDITIONAL DETAILS<\/span><\/h4>\n<p>[\/vc_column_text][vc_empty_space][vc_column_text]<\/p>\n<h5><span style=\"color: #8bc9e0;\"><strong>PATENT OWNERS<\/strong><\/span><\/h5>\n<p style=\"color: #fff; font-weight: bold;\">INFN, UNITN and Fondazione Telethon<\/p>\n<p>[\/vc_column_text][vc_empty_space height=&#8221;21px&#8221;][vc_column_text]<\/p>\n<h5><span style=\"color: #8bc9e0;\"><strong>PRIORITY NUMBER<\/strong><\/span><\/h5>\n<p><strong><span style=\"color: #ffffff;\">IT 102018000007535<\/span><\/strong>[\/vc_column_text][vc_empty_space height=&#8221;21px&#8221;][vc_column_text]<\/p>\n<h5><span style=\"color: #8bc9e0;\"><strong>TECHNOLOGY SECTOR <\/strong><\/span><\/h5>\n<p><strong><span style=\"color: #ffffff;\">Bioinformatics<\/span><\/strong>[\/vc_column_text][vc_empty_space height=&#8221;21px&#8221;][vc_column_text]<\/p>\n<h5><span style=\"color: #8bc9e0;\"><strong>TT CODE<\/strong><\/span><\/h5>\n<p><strong><span style=\"color: #ffffff;\">P_17.021<\/span><\/strong>[\/vc_column_text][vc_empty_space][vc_row_inner row_type=&#8221;row&#8221; type=&#8221;full_width&#8221; text_align=&#8221;left&#8221; css_animation=&#8221;&#8221;][vc_column_inner el_class=&#8221;riga_spazio_progetti&#8221;][\/vc_column_inner][\/vc_row_inner][vc_empty_space][vc_column_text]<\/p>\n<h5><span style=\"color: #8bc9e0;\"><strong>CONTACT US<\/strong><\/span><\/h5>\n<p><strong><span style=\"color: #ffffff;\">For more information about this technology, <\/span><a href=\"mailto:tto@lists.infn.it\"><span style=\"text-decoration: underline;\"><strong><span style=\"color: #ffffff; text-decoration: underline;\">WRITE TO US<\/span><\/strong><\/span><\/a><\/strong>[\/vc_column_text][vc_empty_space][\/vc_column][\/vc_row][vc_row css_animation=&#8221;&#8221; row_type=&#8221;row&#8221; use_row_as_full_screen_section=&#8221;no&#8221; type=&#8221;full_width&#8221; angled_section=&#8221;no&#8221; text_align=&#8221;left&#8221; background_image_as_pattern=&#8221;without_pattern&#8221;][vc_column][vc_empty_space height=&#8221;51px&#8221;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row css_animation=&#8221;&#8221; row_type=&#8221;row&#8221; use_row_as_full_screen_section=&#8221;no&#8221; type=&#8221;full_width&#8221; angled_section=&#8221;no&#8221; text_align=&#8221;left&#8221; background_image_as_pattern=&#8221;without_pattern&#8221;][vc_column][vc_raw_html]W3dwc2VvX2JyZWFkY3J1bWJd[\/vc_raw_html][vc_empty_space][vc_column_text] Method for identifying protein folding intermediates [\/vc_column_text][vc_empty_space][\/vc_column][\/vc_row][vc_row css_animation=&#8221;&#8221; row_type=&#8221;row&#8221; use_row_as_full_screen_section=&#8221;no&#8221; type=&#8221;full_width&#8221; angled_section=&#8221;no&#8221; text_align=&#8221;left&#8221; background_image_as_pattern=&#8221;without_pattern&#8221;][vc_column width=&#8221;2\/3&#8243;][vc_empty_space][vc_column_text]The present technology concerns a computational method for the identification of protein folding intermediates, potentially useful as targets in drug discovery processes.[\/vc_column_text][vc_empty_space][vc_single_image image=&#8221;4346&#8243;&#8230;<\/p>\n","protected":false},"author":6,"featured_media":4346,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","portfolio_category":[264,252],"portfolio_tag":[],"class_list":["post-4345","portfolio_page","type-portfolio_page","status-publish","has-post-thumbnail","hentry","portfolio_category-life-sciences","portfolio_category-patents"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Method for identifying protein folding intermediates - TechTransfer INFN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/web.infn.it\/TechTransfer\/en\/portfolio_page\/method-for-identifying-protein-folding-intermediates\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Method for identifying protein folding intermediates - TechTransfer INFN\" \/>\n<meta property=\"og:description\" content=\"[vc_row css_animation=&#8221;&#8221; row_type=&#8221;row&#8221; use_row_as_full_screen_section=&#8221;no&#8221; type=&#8221;full_width&#8221; angled_section=&#8221;no&#8221; text_align=&#8221;left&#8221; background_image_as_pattern=&#8221;without_pattern&#8221;][vc_column][vc_raw_html]W3dwc2VvX2JyZWFkY3J1bWJd[\/vc_raw_html][vc_empty_space][vc_column_text] Method for identifying protein folding intermediates [\/vc_column_text][vc_empty_space][\/vc_column][\/vc_row][vc_row css_animation=&#8221;&#8221; row_type=&#8221;row&#8221; use_row_as_full_screen_section=&#8221;no&#8221; type=&#8221;full_width&#8221; angled_section=&#8221;no&#8221; text_align=&#8221;left&#8221; background_image_as_pattern=&#8221;without_pattern&#8221;][vc_column width=&#8221;2\/3&#8243;][vc_empty_space][vc_column_text]The present technology concerns a 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