{"id":4744,"date":"2023-12-28T15:28:43","date_gmt":"2023-12-28T14:28:43","guid":{"rendered":"https:\/\/web.infn.it\/TechTransfer\/portfolio_page\/4mica\/"},"modified":"2026-02-05T15:33:04","modified_gmt":"2026-02-05T14:33:04","slug":"4mica","status":"publish","type":"portfolio_page","link":"https:\/\/web.infn.it\/TechTransfer\/en\/portfolio_page\/4mica\/","title":{"rendered":"4MiCA"},"content":{"rendered":"

[vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=””][vc_column][vc_raw_html]W3dwc2VvX2JyZWFkY3J1bWJd[\/vc_raw_html][vc_empty_space][vc_column_text]<\/p>\n

4MiCA<\/h1>\n

[\/vc_column_text][vc_empty_space][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=””][vc_column width=”2\/3″][vc_empty_space][vc_column_text]Miniaturized gas proportional counter (mini-TEPC) for microdosimetric characterization of ion beams used in the treatment of tumours (hadrontherapy). The system is equipped with a user-friendly interface and automated calibration routines, so that it can be easily used in the field even by personnel without specific training in medical physics. Microdosimetry measures the random fluctuation of energy storage in a micrometric volume, which is closely related to the biological efficacy of radiation. The reference detectors are tissue-equivalent gas proportional (TEPC) counters, i.e. built with materials with an elemental composition similar to that of biological tissue.[\/vc_column_text][vc_empty_space][vc_single_image image=”4745″ img_size=”full” qode_css_animation=””][vc_empty_space][vc_column_text]The two main advantages over solid-state detectors are the high sensitivity ensured by the avalanche process and the tissue-equivalence, which minimises disturbance to the radiation field. There is currently only one company that markets TEPCs, but the models produced are not suitable for use in radiotherapy centres, due to their size and\/or because they are designed for a research environment and can therefore only be used by personnel with specific training in microdosimetry. <\/p>\n

 <\/p>\n

The miniaturized TEPCs (mini-TEPCs) developed by INFN can be used on intense beams; they have diameters such that they can be inserted into a cannula and allow measuring at intensities at least 200 times higher than the models on the market. In addition, they have an integrated low-noise preamplifier with a wide dynamic range (more than 4 orders of magnitude) to measure the entire spectrum of LET of interest in hadrontherapy (0.2 \u2013 2000 keV\/\u00b5m). <\/p>\n

 <\/p>\n

The detector was tested at the “A. Lacassaigne” proton therapy centre in Nice, at the CATANA facility<\/a> of LNS, and on carbon ion beams at the CNAO<\/a> in Pavia.[\/vc_column_text][vc_empty_space][\/vc_column][vc_column width=”1\/4″ css=”.vc_custom_1703772967700{margin-bottom: 50px !important;background-color: #042d4c !important;}” el_class=”column_details_portfolio”][vc_column_text]<\/p>\n

INFO<\/span><\/h4>\n

[\/vc_column_text][vc_empty_space][vc_column_text css=”.vc_custom_1703777141639{background-color: #042d4c !important;}”]<\/p>\n

PROJECT MANAGER<\/strong><\/h5>\n

Valeria Conte<\/p>\n

[\/vc_column_text][vc_empty_space height=”21px”][vc_column_text css=”.vc_custom_1703777152349{background-color: #042d4c !important;}”]<\/p>\n

ANNO<\/strong><\/h5>\n

2021<\/span><\/strong>[\/vc_column_text][vc_empty_space height=”21px”][vc_column_text css=”.vc_custom_1720702968288{background-color: #042d4c !important;}”]<\/p>\n

FACILITIES INVOLVED<\/strong><\/h5>\n

Legnaro National Laboratories<\/a><\/strong><\/span>[\/vc_column_text][vc_empty_space height=”21px”][vc_column_text css=”.vc_custom_1714313024158{background-color: #042d4c !important;}”]<\/p>\n

TECHNOLOGY SECTORS<\/strong><\/h5>\n

Radiobiology<\/span><\/strong>
\nParticle therapy<\/span><\/strong>[\/vc_column_text][vc_empty_space height=”21px”][vc_row_inner row_type=”row” type=”full_width” text_align=”left” css_animation=””][vc_column_inner el_class=”riga_spazio_progetti”][\/vc_column_inner][\/vc_row_inner][vc_empty_space height=”21px”][vc_column_text css=”.vc_custom_1720702941822{background-color: #042d4c !important;}”]<\/p>\n

CONTACTS<\/strong><\/h5>\n

For more information about the project, WRITE TO US <\/a>[\/vc_column_text][vc_empty_space height=”21px”][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern”][vc_column][vc_empty_space height=”51px”][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=””][vc_column][vc_raw_html]W3dwc2VvX2JyZWFkY3J1bWJd[\/vc_raw_html][vc_empty_space][vc_column_text] 4MiCA [\/vc_column_text][vc_empty_space][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=””][vc_column width=”2\/3″][vc_empty_space][vc_column_text]Miniaturized gas proportional counter (mini-TEPC) for microdosimetric characterization of ion beams used in the treatment of tumours (hadrontherapy). The system is equipped with a user-friendly interface…<\/p>\n","protected":false},"author":1,"featured_media":4745,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","portfolio_category":[318,323,294,321],"portfolio_tag":[],"class_list":["post-4744","portfolio_page","type-portfolio_page","status-publish","has-post-thumbnail","hentry","portfolio_category-life-sciences-3","portfolio_category-particle-therapy-2","portfolio_category-r4i","portfolio_category-rdiobiology"],"acf":[],"yoast_head":"\n4MiCA - TechTransfer INFN<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/web.infn.it\/TechTransfer\/en\/portfolio_page\/4mica\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"4MiCA - TechTransfer INFN\" \/>\n<meta property=\"og:description\" content=\"[vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=””][vc_column][vc_raw_html]W3dwc2VvX2JyZWFkY3J1bWJd[\/vc_raw_html][vc_empty_space][vc_column_text] 4MiCA [\/vc_column_text][vc_empty_space][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=””][vc_column width=”2\/3″][vc_empty_space][vc_column_text]Miniaturized gas proportional counter (mini-TEPC) for microdosimetric characterization of ion beams used in the treatment of tumours (hadrontherapy). 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