{"id":4817,"date":"2023-12-28T14:42:56","date_gmt":"2023-12-28T13:42:56","guid":{"rendered":"https:\/\/web.infn.it\/TechTransfer\/portfolio_page\/protein-folding\/"},"modified":"2026-02-09T10:29:12","modified_gmt":"2026-02-09T09:29:12","slug":"protein-folding","status":"publish","type":"portfolio_page","link":"https:\/\/web.infn.it\/TechTransfer\/en\/portfolio_page\/protein-folding\/","title":{"rendered":"PROTEIN FOLDING"},"content":{"rendered":"

[vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=””][vc_column][vc_raw_html]W3dwc2VvX2JyZWFkY3J1bWJd[\/vc_raw_html][vc_empty_space][vc_column_text]<\/p>\n

PROTEIN FOLDING
\n<\/span><\/h1>\n

[\/vc_column_text][vc_empty_space][vc_column_text]<\/p>\n

Multi-messenger prediction and validation of the structure of intermediate states in protein folding<\/h2>\n

[\/vc_column_text][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=””][vc_column width=”2\/3″][vc_empty_space][vc_column_text]Basic research within INFN has led to the development of software for the simulation of rare transitions; this project aims to apply these algorithms to the simulation of protein folding, with the aim of identifying target sites for the design of new drugs.<\/p>\n

 <\/p>\n

Computational approaches to drug design are often limited by the complexity of biomolecular processes, which require very high computational capabilities. One example is the very high computational cost required to simulate amyloid protein aggregation that has limited the development of drug therapies for neurodegenerative diseases, such as Alzheimer’s disease.[\/vc_column_text][vc_empty_space][vc_single_image image=”4819″ img_size=”full” qode_css_animation=””][vc_empty_space][vc_column_text]The protocol developed enables the simulation of biomolecular processes with performance comparable to molecular dynamics software running on supercomputers and thus makes it possible to study of drugs that can bind to metastable intermediates in protein folding.
\n\u202f
\nTo realise the Technology Transfer of these technologies in the field of pharmacology, the innovative startup\u202fSibylla Biotech<\/a>, recognised as\u202fINFN Spin-off<\/a> was founded on 5 October 2017.[\/vc_column_text][vc_empty_space][\/vc_column][vc_column width=”1\/4″ css=”.vc_custom_1703772967700{margin-bottom: 50px !important;background-color: #042d4c !important;}” el_class=”column_details_portfolio”][vc_column_text]<\/p>\n

INFO<\/span><\/h4>\n

[\/vc_column_text][vc_empty_space][vc_column_text css=”.vc_custom_1703774420792{background-color: #042d4c !important;}”]<\/p>\n

PROJECT MANAGER<\/strong><\/h5>\n

Pietro Faccioli<\/p>\n

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YEAR<\/strong><\/h5>\n

2019<\/span><\/strong>[\/vc_column_text][vc_empty_space height=”21px”][vc_column_text css=”.vc_custom_1720706747788{background-color: #042d4c !important;}”]<\/p>\n

FACILITIES INVOLVED<\/strong><\/h5>\n

TIFPA<\/span><\/span><\/a><\/strong>[\/vc_column_text][vc_empty_space height=”21px”][vc_column_text css=”.vc_custom_1714312316280{background-color: #042d4c !important;}”]<\/p>\n

TECHNOLOGY SECTORS<\/strong><\/h5>\n

E-health<\/span><\/strong>[\/vc_column_text][vc_empty_space height=”21px”][vc_column_text css=”.vc_custom_1712609365100{background-color: #042d4c !important;}”]<\/p>\n

RELATED TECHNOLOGIES<\/strong><\/h5>\n

P_17.021 <\/span><\/strong>[\/vc_column_text][vc_empty_space height=”21px”][vc_row_inner row_type=”row” type=”full_width” text_align=”left” css_animation=””][vc_column_inner el_class=”riga_spazio_progetti”][\/vc_column_inner][\/vc_row_inner][vc_empty_space height=”21px”][vc_column_text css=”.vc_custom_1720706356140{background-color: #042d4c !important;}”]<\/p>\n

CONTACTS<\/strong><\/h5>\n

For more information about the project, WRITE TO US <\/a><\/p>\n

____________________<\/span><\/p>\n

If you want to get in touch with the spin-off, click here:\u202fSibylla Biotech <\/a> <\/span>[\/vc_column_text][vc_empty_space height=”21px”][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern”][vc_column][vc_empty_space height=”51px”][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=””][vc_column][vc_raw_html]W3dwc2VvX2JyZWFkY3J1bWJd[\/vc_raw_html][vc_empty_space][vc_column_text] PROTEIN FOLDING [\/vc_column_text][vc_empty_space][vc_column_text] Multi-messenger prediction and validation of the structure of intermediate states in protein folding [\/vc_column_text][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=””][vc_column width=”2\/3″][vc_empty_space][vc_column_text]Basic research within INFN has led to the development of software…<\/p>\n","protected":false},"author":1,"featured_media":4818,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","portfolio_category":[320,318,294],"portfolio_tag":[],"class_list":["post-4817","portfolio_page","type-portfolio_page","status-publish","has-post-thumbnail","hentry","portfolio_category-e-health","portfolio_category-life-sciences-3","portfolio_category-r4i"],"acf":[],"yoast_head":"\nPROTEIN FOLDING - 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