{"id":672,"date":"2023-12-28T14:42:56","date_gmt":"2023-12-28T14:42:56","guid":{"rendered":"https:\/\/web.infn.it\/TechTransfer\/?post_type=portfolio_page&p=672"},"modified":"2024-07-11T14:05:58","modified_gmt":"2024-07-11T14:05:58","slug":"protein-folding","status":"publish","type":"portfolio_page","link":"https:\/\/web.infn.it\/TechTransfer\/portfolio_page\/protein-folding\/","title":{"rendered":"PROTEIN FOLDING"},"content":{"rendered":"

[vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=””][vc_column][vc_raw_html]JTVCd3BzZW9fYnJlYWRjcnVtYiU1RA==[\/vc_raw_html][vc_empty_space][vc_column_text]<\/p>\n

PROTEIN FOLDING
\n<\/span><\/h1>\n

[\/vc_column_text][vc_empty_space][vc_column_text]<\/p>\n

Predizione e validazione multi-messenger della struttura di stati intermedi in protein folding<\/h2>\n

[\/vc_column_text][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=””][vc_column width=”2\/3″][vc_empty_space][vc_column_text]La ricerca di base all\u2019interno di INFN ha portato allo sviluppo di software per la simulazione delle transizioni rare; questo progetto ha come finalit\u00e0 l\u2019applicazione di questi algoritmi alla simulazione del ripiegamento delle proteine, con lo scopo di identificare siti bersaglio per il design di nuovi farmaci.<\/p>\n

 <\/p>\n

Gli approcci computazionali al design di farmaci sono spesso limitati dalla complessit\u00e0 dei processi biomolecolari, che richiedono capacit\u00e0 di calcolo elevatissime. Un esempio \u00e8 l\u2019altissimo costo computazionale richiesto per simulare l\u2019aggregazione amiloidogenica delle proteine che ha limitato lo sviluppo di terapie farmacologiche per le malattie neurodegenerative, come il morbo di Alzheimer.[\/vc_column_text][vc_empty_space][vc_single_image image=”2178″ img_size=”full” qode_css_animation=””][vc_empty_space][vc_column_text]Il protocollo sviluppato permette la simulazione dei processi biomolecolari con prestazioni paragonabili a software di dinamica molecolare che girano su supercomputer e rende quindi possibile lo studio di farmaci che possano legarsi a intermedi metastabili nel ripiegamento di proteine.<\/p>\n

 <\/p>\n

Per realizzare il Trasferimento Tecnologico di queste tecnologie in ambito farmacologico, il 5 ottobre 2017 \u00e8 stata fondata la startup innovativa Sibylla Biotech<\/span><\/a>, riconosciuta com e Spinoff INFN.<\/a><\/span>[\/vc_column_text][vc_empty_space][\/vc_column][vc_column width=”1\/4″ css=”.vc_custom_1703772967700{margin-bottom: 50px !important;background-color: #042d4c !important;}” el_class=”column_details_portfolio”][vc_column_text]<\/p>\n

INFO<\/span><\/h4>\n

[\/vc_column_text][vc_empty_space][vc_column_text css=”.vc_custom_1703774420792{background-color: #042d4c !important;}”]<\/p>\n

RESPONSABILE PROGETTO<\/strong><\/h5>\n

Pietro Faccioli<\/p>\n

[\/vc_column_text][vc_empty_space height=”21px”][vc_column_text css=”.vc_custom_1703774430302{background-color: #042d4c !important;}”]<\/p>\n

ANNO<\/strong><\/h5>\n

2019<\/span><\/strong>[\/vc_column_text][vc_empty_space height=”21px”][vc_column_text css=”.vc_custom_1720706747788{background-color: #042d4c !important;}”]<\/p>\n

STRUTTURE COINVOLTE<\/strong><\/h5>\n

TIFPA<\/span><\/span><\/a><\/strong>[\/vc_column_text][vc_empty_space height=”21px”][vc_column_text css=”.vc_custom_1714312316280{background-color: #042d4c !important;}”]<\/p>\n

SETTORI TECNOLOGICI<\/strong><\/h5>\n

E-salute<\/span><\/strong>[\/vc_column_text][vc_empty_space height=”21px”][vc_column_text css=”.vc_custom_1712609365100{background-color: #042d4c !important;}”]<\/p>\n

TECNOLOGIE COLLEGATE<\/strong><\/h5>\n

P_17.021 <\/span><\/strong>[\/vc_column_text][vc_empty_space height=”21px”][vc_row_inner row_type=”row” type=”full_width” text_align=”left” css_animation=””][vc_column_inner el_class=”riga_spazio_progetti”][\/vc_column_inner][\/vc_row_inner][vc_empty_space height=”21px”][vc_column_text css=”.vc_custom_1720706356140{background-color: #042d4c !important;}”]<\/p>\n

CONTATTI<\/strong><\/h5>\n

Per maggiori informazioni sul progetto, <\/span>SCRIVICI<\/span><\/strong><\/span><\/a><\/p>\n

____________________<\/span><\/p>\n

Se vuoi prendere contatti con lo spinoff, clicca qui:<\/strong> Sibylla Biotech <\/strong><\/a><\/span><\/span>[\/vc_column_text][vc_empty_space height=”21px”][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”full_width” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern”][vc_column][vc_empty_space height=”51px”][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

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