Abstract: One of the most intriguing developments in theoretical physics over the past 30 years has been that spacetime might not be a fundamental property of a physical description of nature. Instead, it can emerge from non-geometric matrix degrees of freedom. These matrices furnish the basic building blocks for what has become known as the spacetime hologram. In this big picture talk, I’ll try to explain what this even means, illustrating these ideas with concrete examples such as the AdS/CFT correspondence and the c=1 matrix quantum mechanics. I’ll briefly mention ongoing work to understand the underlying mechanism for this surprising realization.