Come – LARAMED

COME (INFN-CSN3, 2016)

COME, acronym for COpper MEasurement, was a 1-year project, dedicated to the first measurements of the ⁷⁰Zn(p,x)^67,64Cu nuclear reactions above 35 MeV, performed in collaboration with the ARRONAX facility (Saint-Herblain, France).

⁶⁷Cu is an emerging radionuclide, under the spotlight of the scientific community, thanks to its decay characteristics. The ⁶⁷Cu half-life (T_1/2 61.9 h) allows for labeling pharmaceuticals having slow pharmacokinetics, while β⁻/γ radiation (for ⁶⁷Cu) and β⁻/β⁺ emission (for ⁶⁴Cu,T_1/2 12.7 h) are suitable for therapy and SPECT/PET imaging, respectively.

Main steps of the radiochemical separation process developed and optimized in collaboration with the Ferrara University and the Sant’Orsola hospital in Bologna.

Measurement of the nuclear reactions **⁷⁰Zn**(p,x)**^67,64Cu** carried out within the COME project.

Plot of the nuclear cross section ratio for the production of 67Cu and 64Cu radionuclides — Plot of the nuclear cross section ratio for the production of **⁶⁷Cu** and **⁶⁴Cu** radionuclides:
the continuous line is the IAEA recommended value for **⁶⁸Zn** targets; the dashed line refers to the measured values for **⁷⁰Zn** targets. The vertical dashed lines refer to the favorable energy range for **⁶⁷Cu** production. A scheme of the multi-layer target configuration described in the international INFN patent is also shown at the bottom

As shown in the Figures, the ⁷⁰Zn(p,x)^67,64Cu cross section results were the ground for an INFN patent on a multi-layer target to optimize ⁶⁷Cu production exploiting a 70-MeV proton beam and enriched ⁷⁰Zn and ⁶⁸Zn targets, entitled “A method and a target for the production of ⁶⁷Cu”.

More information can be found here:
L. Mou, P. Martini, G. Pupillo, I. Cieszykowska, C.S. Cutler and R. Mikołajczak, ⁶⁷Cu production capabilities: a mini review 2022 Molecules DOI: 10.3390/molecules27051501 https://www.mdpi.com/1420-3049/27/5/1501
G. Pupillo, L. Mou, S. Manenti, F. Groppi, J. Esposito and F. Haddad, Nuclear data for light charged particle induced production of emerging medical radionuclides 2022 Radiochimica Acta DOI: 10.1515/ract-2022-0011 (invited article for the Jubilee issue) https://www.degruyter.com/document/doi/10.1515/ract-2022-0011/html
A.R. Jalilian, M.A. Gizawy, C. Alliot, S. Takacs, S. Chakarborty, M.R. Aboudzadeh Rovais, G. Pupillo et al.,IAEA Activities on ⁶⁷Cu, ¹⁸⁶Re, ⁴⁷Sc Theranostic radionuclides and Radiopharmaceuticals in Current Radiopharmaceuticals (2021) DOI:10.2174/1874471013999200928162322 https://pubmed.ncbi.nlm.nih.gov/32988359/
G. Pupillo, P. Antonini, M. Calderolla, A. Calore, D. Bettoni, A. Boschi, S. Cisternino, A. Duatti, F. Evangelisti, P. Favaron, G. Fiorentini, F. Gramegna, G. Keppel, M. Maggiore, P. Martini, L. Mou, M. Pasquali, L. Pranovi, C. Rossi Alvarez, L. Sarchiapone, G. Sciacca, H. Skliarova and J. Esposito, The Laramed Project at LNL: ⁶⁷Cu and ⁴⁷Sc Production for Theranostic Applications, AIP Conference Proceedings 2295, 020001 (2020); DOI: 10.1063/5.0032898 https://pubs.aip.org/aip/acp/article-abstract/2295/1/020001/747692/The-Laramed-project-at-LNL-67Cu-and-47Sc?redirectedFrom=fulltext
G. Pupillo, L. Mou, P. Martini, M. Pasquali, A. Boschi, G. Cicoria, A. Duatti, F. Haddad and J. Esposito, Production of ⁶⁷Cu by enriched ⁷⁰Zn targets: first measurements of formation cross sections of ⁶⁷Cu, ⁶⁴Cu, ⁶⁷Ga, ⁶⁶Ga,^69mZn and ⁶⁵Zn in interactions of ⁷⁰Zn with protons above 45 MeV Radiochimica Acta(2020) DOI: 10.1515/ract-2019-3199 https://www.degruyter.com/document/doi/10.1515/ract-2019-3199/html
G. Pupillo, T. Sounalet, N. Michel, L. Mou, J. Esposito, F. Haddad, New production cross sections for the theranostic radionuclide ⁶⁷Cu (2018) Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms – Volume 415, Pages 41-47 DOI: 10.1016/j.nimb.2017.10.022 https://www.sciencedirect.com/science/article/abs/pii/S0168583X17309412